The world number five cruised past Russian Aslan Karatsev 6-3, 6-4 in one hour and twenty-four minutes to advance to the third round of the tournament.
"I'm putting (in) hours on the court, trying to become consistent (and) get close to the legends of our sport," Tsitsipas said in his post match interview.
"I am working every single day. I am very far from that, but it is definitely a dream of mine that I want to achieve one day."
He will face either Australian John Millman or Chile's Cristian Garin in the third round.
— ROLEX MC MASTERS (@ROLEXMCMASTERS) April 13, 2021
Earlier, brothers Stefanos and Petros saved two match points to stun No. 8 seeds Kevin Krawietz and Horia Tecau 7-6 (4) 3-6 11-9 in their Monte Carlo Masters doubles opener.