The Greek champion is one of the favourites to lift the US Open title, though he refuses to look beyond his tricky first-round against Andy Murray.
Amid major names pulling out with injury - including Rafael Nadal, Roger Federer and Dominic Thiem - he wants to make sure he does not slip up against the 34-year-old Scot.
One of three British in the men’s main draw, Murray lifted the title back in 2012 and has a 65% win percentage against top 10 opponents.
“I’m focusing on what’s next,” said Tsitsipas. “This is way too deep to look into. I’ve got to stay in the moment.”
“He [Murray] is still on. He’s someone that has been putting a lot of work in to get back and has been playing very good tennis to be standing where he is at right now.
“I’m going to go for it, try my chances against him. He’s someone that won’t give up. I’ll have to bring some good tennis from my side.”
See Stef's #Tsitsipas pre-tournament press conference