No.4 Tistispas had to battle back from two sets down against Lorenzo Musetti to win 5-7, 4-6, 6-2, 6-3, 6-2.
Stefanos Tsitsipas completed the third comeback win from two sets down of his career on Tuesday, defeating Lorenzo Musetti 5-7 4-6 6-2 6-3 6-2 at the French Open.
Before moving to a 2-0 head-to-head record over Musetti, the fourth-seed Greek's last such victory was against Rafael Nadal in the quarter-finals at the 2021 Australian Open.
Tsitsipas needed to draw on that experience and dig deep after only winning 60 per cent of points on his first serve in the first two sets on Tuesday, then winning 15 of 17 points in the deciding set.
Post-match, world number four explained how he needed to isolate his focus on each point and build from thereafter going two sets down.
"Things don't come easy. I refuse to give up. That's simply how it works with me," Tsitsipas said. "You never really think about getting back after being two sets to love. You just play it point after point. You just wish that your efforts will pay off on a longer scale, in the longer run.
"Being in that situation, it's a mountain that you have to climb, and I was able to climb it and regain the momentum steadily, but consistently."
Kolar is next for Stefanos in Round 2