Medvedev boasted a 7-2 head-to-head record against world number seven Tsitsipas heading into the clash but the Greek got the edge with a 7-6 (8-6) 3-6 6-3 win in two hours and 23 minutes.
Tsitsipas' net play was a feature in the victory, winning 27 of 36 points at the net, while he won 82 per cent of his first serve points. He hit 33-28 winners while Medvedev gave up 35-27 unforced errors with the Russian also having 11 double faults, including a key break in the third set.
Medvedev boasted a 7-2 head-to-head record against world number seven Tsitsipas heading into the clash but the Greek got the edge with a 7-6 (8-6) 3-6 6-3 win in two hours and 23 minutes.
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