Tsitsipas, who dropped only one set in the entire tournament, closed the match in 69 minutes to add a second title in the claycourt win after winning last month's Monte Carlo Masters.
Second seed Stefanos Tsitsipas claimed his seventh ATP title after beating Britain's Cameron Norrie 6-3, 6-3 in the final of the Lyon Open on Sunday.
Tsitsipas, who dropped only one set in the entire tournament, wrapped up the match in 69 minutes to add a second title in the claycourt after winning last month's Monte Carlo Masters.
"I felt like things were going my way. I'm proud of this performance against Cameron since he's been winning against big players and showing what left-handers can do on clay," Tsitsipas said in a post-match interview on court.
Speaking of his plans ahead of the French Open later this month, he said: "It's about getting there as early as possible, starting practice and getting in shape for the big Parisian Grand Slam, which I adore and love.
"Hopefully, something good can come out of it."
The 22-year-old Greek won on the back of a strong service game, winning 82 per cent of his first-serve points while he broke Norrie three times in the match.
Tsitsipas, ranked fifth in the world, also leads the ATP Race to Turin's season-ending tournament with 33 wins this year.