Researchers from seven Greek universities and research institutes have developed a new artificial intelligence application that predicts life-threatening ruptures of abdominal aortic aneurysms (AAA).
Abdominal aortic aneurysm ranks as the 13th leading cause of death and the third leading cause of sudden death in Western countries. When an aneurysm ruptures, patients face an estimated mortality rate of 80 percent. Because aneurysms often develop without symptoms, doctors frequently discover them only during medical emergencies.
The research team created the AI tool, called SAFE-AORTA, to close this critical gap in early detection. Christos Manopoulos, the project coordinator and director of the National Technical University of Athens (NTUA) Biofluids Laboratory, described SAFE-AORTA as a “clinical decision support system” that helps doctors identify patients at high risk of rupture.
SAFE-AORTA analyses a broad range of patient data, including CT scans, blood flow velocity measurements, and detailed medical histories. Based on this information, the system builds a “digital twin” of each patient’s aorta, enabling doctors to track changes over time and assess rupture risk with greater accuracy.
The platform updates the digital model continuously using data from smartwatches and regular physician input. This ongoing monitoring allows doctors to move beyond one-time assessments and respond more effectively to changes in a patient’s condition. Researchers believe this approach can significantly improve prevention, enable timely medical intervention, and increase survival rates for patients with abdominal aortic aneurysms.

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