From Tuesday, Thessaloniki and Serres will be on lockdown for two weeks.
"While the figures show that even now Greece is among the countries with a better epidemiological picture, the coronavirus cases are showing exponential growth in Greece," government spokesperson Stelios Petsas said.
Greece has reported fewer covid-19 cases than most in Europe, but it has seen a significant increase in infections since early October.
Contrary to the lockdown earlier this year, schools will remain open while the sending of SMS for movements outside the home will be applied again. Additionally, there will be a curfew from 9pm-5am, with only movements for reasons of health or work excepted.
Domestic and international flights to and from Thessaloniki will also be suspended for 14 days for non-essential reason.
Latest covid-19 numbers in Greece
Greece recorded 1,152 new cases of COVID-19 in the latest 24-hour reporting period.
This raises the total number of cases to 42,080.
4,176 are considered to be related to travel from abroad and 13,821 are related to an already known case.
One hundred and fifty-three individuals are in ICU. Their median age is 66 years, and 35 of them are women. 90.8% have an underlying condition or are aged 70 years and above.
A total of 294 patients have been discharged from ICUs since the start of the pandemic in Greece.
The country’s pandemic death toll stands at 642. The median age of all was 79 years and 96.3% of the deceased had an underlying condition and/or age of 70 years or more.
Earlier this month,the government launched an interactive COVID-19 mapthat allows citizens and visitors to quickly find out more about the epidemiological situation across Greece and discover the measures that are in effect. Please click here for the website-covid19.gov.gr.